Active immunization of mice with an Abeta-Hsp70 vaccine.

@article{Koller2004ActiveIO,
  title={Active immunization of mice with an Abeta-Hsp70 vaccine.},
  author={Michael F Koller and M. Hasan Mohajeri and Michael Huber and Marc Axel Wollmer and Birgit V Roth Z'graggen and Erika Sandmeier and Eva Moritz and J Dustin Tracy and Roger M. Nitsch and Philipp Christen},
  journal={Neuro-degenerative diseases},
  year={2004},
  volume={1 1},
  pages={20-8}
}
Heat-shock proteins are highly immunogenic. Complexed with an antigen, they act as adjuvants, inducing a humoral and cellular immune response against both the antigen and the chaperone. In this study, we produced an Hsp70-supported vaccine to induce the generation of antibodies against amyloid-beta (Abeta) peptides, the major constituent of beta-amyloid plaques in Alzheimer's disease. The vaccine consisted of synthetic human Abeta42 covalently cross-linked with DnaK, an Hsp70 homolog of… CONTINUE READING

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In this study , we produced an Hsp70-supported vaccine to induce the generation of antibodies against amyloid - beta ( Abeta ) peptides , the major constituent of beta - amyloid plaques in Alzheimer 's disease .
In this study , we produced an Hsp70-supported vaccine to induce the generation of antibodies against amyloid - beta ( Abeta ) peptides , the major constituent of beta - amyloid plaques in Alzheimer 's disease .
Active immunization of mice with this vaccine resulted in the generation of antibodies against Abeta , that were detectable in sera after the first booster immunization .
Active immunization of mice with this vaccine resulted in the generation of antibodies against Abeta , that were detectable in sera after the first booster immunization .
In this study , we produced an Hsp70-supported vaccine to induce the generation of antibodies against amyloid - beta ( Abeta ) peptides , the major constituent of beta - amyloid plaques in Alzheimer 's disease .
In this study , we produced an Hsp70-supported vaccine to induce the generation of antibodies against amyloid - beta ( Abeta ) peptides , the major constituent of beta - amyloid plaques in Alzheimer 's disease .
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