Active human nucleolar organizer regions are interspersed with inactive rDNA repeats in normal and tumor cells.

@article{Zillner2015ActiveHN,
  title={Active human nucleolar organizer regions are interspersed with inactive rDNA repeats in normal and tumor cells.},
  author={Karina Zillner and Jun Komatsu and Katharina Filarsky and Rajakiran Kalepu and Aaron Bensimon and Attila N{\'e}meth},
  journal={Epigenomics},
  year={2015},
  volume={7 3},
  pages={363-78}
}
AIM The synthesis of rRNA is a key determinant of normal and malignant cell growth and subject to epigenetic regulation. Yet, the epigenomic features of rDNA arrays clustered in nucleolar organizer regions are largely unknown. We set out to explore for the first time how DNA methylation is distributed on individual rDNA arrays. MATERIALS & METHODS Here we combined immunofluorescence detection of DNA modifications with fluorescence hybridization of single DNA fibers, metaphase immuno-FISH and… CONTINUE READING
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Single-molecule analysis of combinatorial epigenomic states in normal and tumor cells.

Proceedings of the National Academy of Sciences of the United States of America • 2013

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