Active fraction (HS7) from Taiwanofungus camphoratus inhibits AKT-mTOR, ERK and STAT3 pathways and induces CDK inhibitors in CL1-0 human lung cancer cells

@inproceedings{Lai2017ActiveF,
  title={Active fraction (HS7) from Taiwanofungus camphoratus inhibits AKT-mTOR, ERK and STAT3 pathways and induces CDK inhibitors in CL1-0 human lung cancer cells},
  author={I-Chun Lai and Gi-Ming Lai and J. Ba Chow and Hsin-Lun Lee and Chuan-Feng Yeh and Chi-Han Li and Jiann-Long Yan and Shuang-En Chuang and J. Whang-Peng and Kuan-Jen Bai and Chih-Jung Yao},
  booktitle={Chinese medicine},
  year={2017}
}
BackgroundThe non-small cell lung cancer (NSCLC) is the leading cause of cancer death worldwide. In NSCLC, the oncogenic AKT-mTOR, ERK and STAT3 pathways are commonly dysregulated and have emerged as attractive targets for therapeutic developments. In a relatively limited subset of NSCLC, these pathways driven by mutant EGFR can be treated by the tyrosine kinase inhibitors (TKIs)-mediated targeted therapy. However, for the most NSCLC, more novel targeted agents are imperatively needed… CONTINUE READING
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