Active elasticity drives the formation of periodic beading in damaged axons.

  title={Active elasticity drives the formation of periodic beading in damaged axons.},
  author={D. Riccobelli},
  journal={Physical review. E},
  volume={104 2-1},
  • D. Riccobelli
  • Published 3 July 2021
  • Medicine, Physics
  • Physical review. E
In several pathological conditions, such as coronavirus infections, multiple sclerosis, Alzheimer's and Parkinson's diseases, the physiological shape of axons is altered and a periodic sequence of bulges appears. Experimental evidences suggest that such morphological changes are caused by the disruption of the microtubules composing the cytoskeleton of the axon. In this paper, we develop a mathematical model of damaged axons based on the theory of continuum mechanics and nonlinear elasticity… 

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