Active diffusion positions the nucleus in mouse oocytes

@article{Almonacid2015ActiveDP,
  title={Active diffusion positions the nucleus in mouse oocytes},
  author={Maria Almonacid and W. Ahmed and Matthias Bussonnier and P. Mailly and T. Betz and R. Voituriez and N. Gov and M. Verlhac},
  journal={Nature Cell Biology},
  year={2015},
  volume={17},
  pages={470-479}
}
In somatic cells, the position of the cell centroid is dictated by the centrosome. The centrosome is instrumental in nucleus positioning, the two structures being physically connected. Mouse oocytes have no centrosomes, yet harbour centrally located nuclei. We demonstrate how oocytes define their geometric centre in the absence of centrosomes. Using live imaging of oocytes, knockout for the formin 2 actin nucleator, with off-centred nuclei, together with optical trapping and modelling, we… Expand
Control of nucleus positioning in mouse oocytes.
F-actin mechanics control spindle centring in the mouse zygote
Dynamic organelle distribution initiates actin-based spindle migration in mouse oocytes
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