Active chromatin

@article{Weisbrod1982ActiveC,
  title={Active chromatin},
  author={Stuart Weisbrod},
  journal={Nature},
  year={1982},
  volume={297},
  pages={289-295}
}
Active genes are packaged into an altered nucleosome structure forming a chromosomal domain defined by increased sensitivity to nucleases. This structure, reflecting a potential for transcription, contains sites hypersensitive to nuclease digestion adjacent to the coding regions and may also be distinguished by specific non-histone proteins, variant or modified histones or modified DNA. Its formation, by unfolding of a tightly packed chromatin fibre by factors which might affect DNA… CONTINUE READING

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