Active cage mechanism of chaperonin-assisted protein folding demonstrated at single-molecule level.

@article{Gupta2014ActiveCM,
  title={Active cage mechanism of chaperonin-assisted protein folding demonstrated at single-molecule level.},
  author={Amit J. Gupta and Shubhasis Haldar and Goran Mili{\vc}i{\'c} and F. Ulrich Hartl and Manajit Hayer-Hartl},
  journal={Journal of molecular biology},
  year={2014},
  volume={426 15},
  pages={2739-54}
}
The cylindrical chaperonin GroEL and its lid-shaped cofactor GroES of Escherichia coli have an essential role in assisting protein folding by transiently encapsulating non-native substrate in an ATP-regulated mechanism. It remains controversial whether the chaperonin system functions solely as an infinite dilution chamber, preventing off-pathway aggregation, or actively enhances folding kinetics by modulating the folding energy landscape. Here we developed single-molecule approaches to… CONTINUE READING
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