Active borna disease virus polymerase complex requires a distinct nucleoprotein-to-phosphoprotein ratio but no viral X protein.

@article{Schneider2003ActiveBD,
  title={Active borna disease virus polymerase complex requires a distinct nucleoprotein-to-phosphoprotein ratio but no viral X protein.},
  author={Urs Schneider and Melanie Naegele and Peter Staeheli and Martin Schwemmle},
  journal={Journal of virology},
  year={2003},
  volume={77 21},
  pages={11781-9}
}
Analysis of the composition and regulation of the Borna disease virus (BDV) polymerase complex has so far been limited by the lack of a functional assay. To establish such an assay on the basis of an artificial minigenome, we constructed expression vectors encoding either nucleoprotein (N), phosphoprotein (P), X protein, or polymerase (L) of BDV under the control of the chicken beta-actin promoter. A Flag-tagged version of L colocalized with virus-encoded N and P in characteristic nuclear dots… CONTINUE READING

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