Active and higher intracellular uptake of 5-aminolevulinic acid in tumors may be inhibited by glycine.

@article{Langer1999ActiveAH,
  title={Active and higher intracellular uptake of 5-aminolevulinic acid in tumors may be inhibited by glycine.},
  author={Stefan F. J. Langer and Christoph Abels and Andreas Botzlar and Sascha A. Pahernik and Kyle Rick and R. M. Szeimies and Alwin Eduard Goetz},
  journal={The Journal of investigative dermatology},
  year={1999},
  volume={112 5},
  pages={723-8}
}
Topical 5-aminolevulinic acid is used for the fluorescence-based diagnosis and photodynamic treatment of superficial precancerous and cancerous lesions of the skin. Thus, we investigated the kinetics of 5-aminolevulinic acid-induced fluorescence and the mechanisms responsible for the selective formation of porphyrins in tumors in vivo. Using amelanotic melanomas (A-Mel-3) grown in dorsal skinfold chambers of Syrian golden hamsters fluorescence kinetics were measured up to 24 h after topical… CONTINUE READING