Active and acid-activatable TGF-beta in human sera, platelets and plasma.

@article{Grainger1995ActiveAA,
  title={Active and acid-activatable TGF-beta in human sera, platelets and plasma.},
  author={David John Grainger and Dan Mosedale and James C. Metcalfe and Peter L. Weissberg and Paul M. Kemp},
  journal={Clinica chimica acta; international journal of clinical chemistry},
  year={1995},
  volume={235 1},
  pages={11-31}
}
Assays which measure active and latent forms of transforming growth factor beta (TGF-beta) separately in human serum and plasma are required to investigate the biological role of TGF-beta in a variety of human diseases. We have developed an enzyme-linked immunosorbent assay (ELISA) using two polyclonal antibodies against TGF-beta which rapidly determines the amount of active plus acid-activatable, latent TGF-beta forms ((a+l)TGF-beta) present in human serum and plasma in the range 4 pmol/l to… CONTINUE READING
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