[Active analog of the inactive "sleep peptide"].


Delta Sleep-Inducing Peptide (DSIP) was not previously found to possess hypnogenic properties. Its analogue (D-TrpI)DSIP was more stable against aminopeptidases. Its intracerebrovascular administration in doses of 0.7, 7 and 70 micrograms/kg body weight induced a significant increase in slow wave sleep (by 40%; p less than 0.01, U-test) and rectal temperature elevation (by 0.9 degrees C; p less than 0.01) within the following 3 day-light hours, as compared to the control rabbits treated with physiologic saline. Intravenous injections of the DSIP analogue increased slow wave sleep by 25% in a narrow dose range (30-70 micrograms/kg).

Cite this paper

@article{Kovalzon1986ActiveAO, title={[Active analog of the inactive "sleep peptide"].}, author={V. M. Koval'zon and V. N. Kalikhevich and S. I. Churkina}, journal={Biulleten' eksperimental'noĭ biologii i meditsiny}, year={1986}, volume={101 6}, pages={707-9} }