Active Tumor Permeation and Uptake of Surface Charge-Switchable Theranostic Nanoparticles for Imaging-Guided Photothermal/Chemo Combinatorial Therapy.

@article{Hung2016ActiveTP,
  title={Active Tumor Permeation and Uptake of Surface Charge-Switchable Theranostic Nanoparticles for Imaging-Guided Photothermal/Chemo Combinatorial Therapy.},
  author={Chia-Chian Hung and Wen-Chia Huang and Y. Y. Lin and Ting-Wei Yu and Hsin-Hung Chen and Sung-Chyr Lin and Wen-Hsuan Chiang and Hsin-Cheng Chiu},
  journal={Theranostics},
  year={2016},
  volume={6 3},
  pages={302-17}
}
To significantly promote tumor uptake and penetration of therapeutics, a nanovehicle system comprising poly(lactic-co-glycolic acid) (PLGA) as the hydrophobic cores coated with pH-responsive N-acetyl histidine modified D-α-tocopheryl polyethylene glycol succinate (NAcHis-TPGS) is developed in this work. The nanocarriers with switchable surface charges in response to tumor extracellular acidity (pHe) were capable of selectively co-delivering indocyanine green (ICG), a photothermal agent, and… CONTINUE READING
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