Active Trafficking of Alpha 1 Antitrypsin across the Lung Endothelium

  title={Active Trafficking of Alpha 1 Antitrypsin across the Lung Endothelium},
  author={Angelia D. Lockett and Mary Beth Brown and Nieves Santos-Falcon and Natalia I. Rush and Houssam Oueini and Amber J. Oberle and Esther M Bolanis and Miryam A. Fragoso and Daniela Nicoleta Petruşcă and Karina A Serban and Kelly S. Schweitzer and Robert G. Presson and Michael A Campos and Irina Petrache},
  booktitle={PloS one},
The homeostatic lung protective effects of alpha-1 antitrypsin (A1AT) may require the transport of circulating proteinase inhibitor across an intact lung endothelial barrier. We hypothesized that uninjured pulmonary endothelial cells transport A1AT to lung epithelial cells. Purified human A1AT was rapidly taken up by confluent primary rat pulmonary endothelial cell monolayers, was secreted extracellularly, both apically and basolaterally, and was taken up by adjacent rat lung epithelial cells… CONTINUE READING