Active Src elevates the expression of beta-catenin by enhancement of cap-dependent translation.

@article{Karni2005ActiveSE,
  title={Active Src elevates the expression of beta-catenin by enhancement of cap-dependent translation.},
  author={Rotem Karni and Yael Gus and Yuval Dor and Oded Meyuhas and Alexander Levitzki},
  journal={Molecular and cellular biology},
  year={2005},
  volume={25 12},
  pages={5031-9}
}
The proto-oncogene pp60(c-Src) (c-Src) is activated in many types of cancer and contributes to the transformed phenotype of the tumor, although its role is not yet fully understood. Here we report that active Src elevates the levels of beta-catenin by enhancing cap-dependent translation. Src induces phosphorylation of the eukaryotic initiation factor 4E via the Ras/Raf/ERK pathway and the phosphorylation of its inhibitor 4E-BP1 via the PI3K/mTOR pathway. Activated Src enhances the accumulation… CONTINUE READING

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