Active Rho is localized to podosomes induced by oncogenic Src and is required for their assembly and function

@article{Berdeaux2004ActiveRI,
  title={Active Rho is localized to podosomes induced by oncogenic Src and is required for their assembly and function},
  author={Rebecca Berdeaux and B. Zabala Diaz and Lomi Kim and G. Steven Martin},
  journal={The Journal of Cell Biology},
  year={2004},
  volume={166},
  pages={317 - 323}
}
Transformation of fibroblasts by oncogenic Src causes disruption of actin stress fibers and formation of invasive adhesions called podosomes. Because the small GTPase Rho stimulates stress fiber formation, Rho inactivation by Src has been thought to be necessary for stress fiber disruption. However, we show here that Rho[GTP] levels do not decrease after transformation by activated Src. Inactivation of Rho in Src-transformed fibroblasts by dominant negative RhoA or the Rho-specific inhibitor C3… CONTINUE READING

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