Active Repression of Antiapoptotic Gene Expression by RelA(p65) NF-κB

@inproceedings{Campbell2004ActiveRO,
  title={Active Repression of Antiapoptotic Gene Expression by RelA(p65) NF-κB},
  author={Kirsteen J Campbell and Sonia Rocha and Neil D Perkins},
  year={2004}
}
Abstract With the emerging role of NF-κB in cancer it is important that its responses to stimuli relevant to tumor progression and therapy are understood. Here, we demonstrate that NF-κB induced by cytotoxic stimuli, such as ultraviolet light (UV-C) and the chemotherapeutic drugs daunorubicin/doxorubicin, is functionally distinct to that seen with the inflammatory cytokine TNF and is an active repressor of antiapoptotic gene expression. Surprisingly, these effects are mediated by the RelA(p65… CONTINUE READING

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