Active Remodeling of Cortical Actin Regulates Spatiotemporal Organization of Cell Surface Molecules

@article{Gowrishankar2012ActiveRO,
  title={Active Remodeling of Cortical Actin Regulates Spatiotemporal Organization of Cell Surface Molecules},
  author={Kripa Gowrishankar and Subhasri Ghosh and Suvrajit Saha and C. Rumamol and Satyajit Mayor and M. Rammohan Rao},
  journal={Cell},
  year={2012},
  volume={149},
  pages={1353-1367}
}
Many lipid-tethered proteins and glycolipids exist as monomers and nanoclusters on the surface of living cells. The spatial distribution and dynamics of formation and breakup of nanoclusters does not reflect thermal and chemical equilibrium and is controlled by active remodeling of the underlying cortical actin. We propose a model for nanoclustering based on active hydrodynamics, wherein cell surface molecules bound to dynamic actin are actively driven to form transient clusters. This… CONTINUE READING
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Dynamics of shape and composition of an active composite membrane

  • K. Gowrishankar
  • PhD thesis,
  • 2009
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