Active PAI-1 as marker for venous thromboembolism: case-control study using a comprehensive panel of PAI-1 and TAFI assays.

@article{Bollen2014ActivePA,
  title={Active PAI-1 as marker for venous thromboembolism: case-control study using a comprehensive panel of PAI-1 and TAFI assays.},
  author={Lize Bollen and Marijke Peetermans and Miet Peeters and Kristel van Steen and Marc F Hoylaerts and Paul J Declerck and Peter B. Verhamme and Ann Gils},
  journal={Thrombosis research},
  year={2014},
  volume={134 5},
  pages={1097-102}
}
BACKGROUND Both activated Thrombin Activatable Fibrinolysis Inhibitor (TAFI) and active Plasminogen Activator Inhibitor-1 (PAI-1) attenuate fibrinolysis and may therefore contribute to the pathophysiology of Venous ThromboEmbolism (VTE). Whether increased TAFI and/or PAI-1 concentrations are associated with VTE is unclear. OBJECTIVE To study an association of impaired fibrinolysis and VTE using a comprehensive panel of in-house developed assays measuring intact TAFI, activation peptide of… CONTINUE READING