Active Microphase Separation in Mixtures of Microtubules and Tip-Accumulating Molecular Motors

@article{Lemma2022ActiveMS,
  title={Active Microphase Separation in Mixtures of Microtubules and Tip-Accumulating Molecular Motors},
  author={Bezia Lemma and Noah P. Mitchell and Radhika Subramanian and Daniel J. Needleman and Zvonimir Dogic},
  journal={Physical Review X},
  year={2022}
}
Mixtures of filaments and molecular motors form active materials with diverse dynamical behaviors that vary based on their constituents ’ molecular properties. To develop a multiscale of these materials, we map the nonequilibrium phase diagram of microtubules and tip-accumulating kinesin-4 molecular motors. We find that kinesin-4 can drive either global contractions or turbulentlike extensile dynamics, depending on the concentrations of both microtubules and a bundling agent. We also observe a… 

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Extensile to contractile transition in active microtubule–actin composites generates layered asters with programmable lifetimes

Significance Active forces sculpt the forms of living things, generating adaptable and reconfigurable dynamical materials. Creating synthetic materials that exhibit comparable control over internally
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