Active Drug Metabolites

  title={Active Drug Metabolites},
  author={S. Garattini},
  journal={Clinical Pharmacokinetics},
  • S. Garattini
  • Published 1985
  • Medicine
  • Clinical Pharmacokinetics
  • SummaryThis review underlines the importance of considering in the overall evaluation of drug effect and efficacy not only the kinetics and activities of the administered drug, but also those of the chemical species (metabolites) which are formed in the body. The circumstances in which a role for active drug metabolites may be suspected are described, and a number of specific examples are given.Four different categories are described: drugs which are inactive precursors of active metabolites (e… CONTINUE READING
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