Active Drug Metabolites

@article{Garattini1985ActiveDM,
  title={Active Drug Metabolites},
  author={Silvio Ken Garattini},
  journal={Clinical Pharmacokinetics},
  year={1985},
  volume={10},
  pages={216-227}
}
  • S. Garattini
  • Published 1 May 1985
  • Biology
  • Clinical Pharmacokinetics
SummaryThis review underlines the importance of considering in the overall evaluation of drug effect and efficacy not only the kinetics and activities of the administered drug, but also those of the chemical species (metabolites) which are formed in the body. The circumstances in which a role for active drug metabolites may be suspected are described, and a number of specific examples are given.Four different categories are described: drugs which are inactive precursors of active metabolites (e… 

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