Active DNA demethylation in post-mitotic neurons: A reason for optimism

@article{Gavin2013ActiveDD,
  title={Active DNA demethylation in post-mitotic neurons: A reason for optimism},
  author={David P. Gavin and Kayla A Chase and Rajiv P. Sharma},
  journal={Neuropharmacology},
  year={2013},
  volume={75},
  pages={233-245}
}
Over the last several years proteins involved in base excision repair (BER) have been implicated in active DNA demethylation. We review the literature supporting BER as a means of active DNA demethylation, and explain how the various components function and cooperate to remove the potentially most enduring means of epigenetic gene regulation. Recent evidence indicates that the same pathways implicated during periods of widespread DNA demethylation, such as the erasure of methyl marks in the… CONTINUE READING

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