Active Control of Droplet Formation Process in Microfluidics

  title={Active Control of Droplet Formation Process in Microfluidics},
  author={Nam-Trung Nguyen and Say Hwa Tan},
Controlling the size and the monodispersity of droplets is an important task in droplet-based microfluidics. A closed-loop control mechanism with actuation and sensing of droplet size is ideal for systems that require a high degree of monodispersity. Most droplet-based microfluidic systems control the size of droplets using the flow rates, applied pressures, and flow rate ratios. These concepts are based on the hydrodynamic interactions during the formation process of droplets and requires a… 


Thermally mediated droplet formation in microchannels
Precise dispensing of microdroplets is an important process for droplet-based microfluidics. The dropletformation by shear force between two immiscible fluids depends on their flow rates, the
Shear force induced monodisperse droplet formation in a microfluidic device by controlling wetting properties.
Perpendicular flow is used to induce oil droplet breakup by using a capillary as water phase flow channel and two quantitative equations utilized to predict the droplet size are developed.
Microscale tipstreaming in a microfluidic flow focusing device
A microfluidic flow-focusing device is used to explore the use of surfactant-mediated tipstreaming to synthesize micrometer-scale and smaller droplets. By controlling the surfactant bulk
Preparation of highly monodisperse droplet in a T‐junction microfluidic device
In our previous work, a new flow route was developed—a so-called perpendicular shear force–induced droplet formation—in a self-designed simple T-junction microchannel device. In this work, the
Formation of droplets of alternating composition in microfluidic channels and applications to indexing of concentrations in droplet-based assays.
A method for creating droplet pairs by generating alternating droplets, of two sets of aqueous solutions in a flow of immiscible carrier fluid within PDMS and glass microfluidic channels is characterized.
Formation of droplets and bubbles in a microfluidic T-junction-scaling and mechanism of break-up.
Experimental results support the assertion that the dominant contribution to the dynamics of break-up arises from the pressure drop across the emerging droplet or bubble.
Controlled production of monodisperse double emulsions by two-step droplet breakup in microfluidic devices.
A microfluidic device having both hydrophobic and hydrophilic components is exploited for production of multiple-phase emulsions. For producing water-in-oil-in-water (W/O/W) dispersions, aqueous
Droplet formation in a microchannel network.
A method is given for generating droplets in a microchannel network. With oil as the continuous phase and water as the dispersed phase, pico/nanoliter-sized water droplets can be generated in a
Formation of bubbles and droplets in microfluidic systems
This mini-review reports the recent advances in the hydrodynamic techniques for formation of bubbles of gas in liquid in microfluidic systems. Systems comprising ducts that have widths of the order
Controlled formulation of monodisperse double emulsions in a multiple-phase microfluidic system.
This paper gives an overview of the recent work on the use of microfluidic devices to formulate double emulsions, which has enabled the production of organic droplets that encase two aqueous droplets of differing compositions.