Active Ca2+/Calmodulin-Dependent Protein Kinase IIγB Impairs Positive Selection of T Cells by Modulating TCR Signaling1

  title={Active Ca2+/Calmodulin-Dependent Protein Kinase II$\gamma$B Impairs Positive Selection of T Cells by Modulating TCR Signaling1},
  author={Maureen A. McGargill and Leslie Lynne Sharp and Jack D. Bui and Stephen M. Hedrick and S{\'e}bastien Calbo},
  journal={The Journal of Immunology},
  pages={656 - 664}
T cell development is regulated at two critical checkpoints that involve signaling events through the TCR. These signals are propagated by kinases of the Src and Syk families, which activate several adaptor molecules to trigger Ca2+ release and, in turn, Ca2+/calmodulin-dependent protein kinase II (CaMKII) activation. In this study, we show that a constitutively active form of CaMKII antagonizes TCR signaling and impairs positive selection of thymocytes in mice. Following TCR engagement, active… 

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  • K. Machaca
  • Biology
    Journal of Biological Chemistry
  • 2003
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