Active Adenoviral Vascular Penetration by Targeted Formation of Heterocellular Endothelial–epithelial Syncytia

@inproceedings{Chen2011ActiveAV,
  title={Active Adenoviral Vascular Penetration by Targeted Formation of Heterocellular Endothelial–epithelial Syncytia},
  author={Hannah H. Chen and Ryan Cawood and Yasser El-Sherbini and Laura Purdie and Miriam Bazan-Peregrino and Leonard W Seymour and Robert C. Carlisle},
  booktitle={Molecular therapy : the journal of the American Society of Gene Therapy},
  year={2011}
}
The endothelium imposes a structural barrier to the extravasation of systemically delivered oncolytic adenovirus (Ad). Here, we introduced a transendothelial route of delivery in order to increase tumor accumulation of virus particles (vp) beyond that resulting from convection-dependent extravasation alone. This was achieved by engineering an Ad encoding a syncytium-forming protein, gibbon ape leukemia virus (GALV) fusogenic membrane glycoprotein (FMG). The expression of GALV was regulated by a… CONTINUE READING

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