Activators of the farnesoid X receptor negatively regulate androgen glucuronidation in human prostate cancer LNCAP cells.

@article{Kaeding2008ActivatorsOT,
  title={Activators of the farnesoid X receptor negatively regulate androgen glucuronidation in human prostate cancer LNCAP cells.},
  author={Jenny Kaeding and Emmanuel Bouchaert and Julie Belanger and Patrick Caron and Sarah Chouinard and M{\'e}lanie Verreault and Olivier Larouche and Georges Pelletier and Bart Staels and Alain B{\'e}langer and Olivier Barbier},
  journal={The Biochemical journal},
  year={2008},
  volume={410 2},
  pages={245-53}
}
Androgens are major regulators of prostate cell growth and physiology. In the human prostate, androgens are inactivated in the form of hydrophilic glucuronide conjugates. These metabolites are formed by the two human UGT2B15 [UGT (UDP-glucuronosyltransferase) 2B15] and UGT2B17 enzymes. The FXR (farnesoid X receptor) is a bile acid sensor controlling hepatic and/or intestinal cholesterol, lipid and glucose metabolism. In the present study, we report the expression of FXR in normal and cancer… CONTINUE READING