Activators of peroxisome proliferator-activated receptors protect human skin from ultraviolet-B-light-induced inflammation.

@article{Kippenberger2001ActivatorsOP,
  title={Activators of peroxisome proliferator-activated receptors protect human skin from ultraviolet-B-light-induced inflammation.},
  author={Stefan Kippenberger and Stefan M. Loitsch and Marcella Grundmann-Kollmann and St{\'e}phane R J Simon and Tuan Anh Dang and Katja Hardt-Weinelt and Roland Kaufmann and August Bernd},
  journal={The Journal of investigative dermatology},
  year={2001},
  volume={117 6},
  pages={1430-6}
}
Peroxisome proliferator-activated receptors (PPAR) are members of a nuclear receptor superfamily, which were initially described in the context of fatty acid degradation and adipocyte differentiation. In this study we tested the hypothesis that peroxisome proliferator-activated receptor activation also controls inflammation. In an in vitro model with human keratinocytes inflammation was mimicked by irradiation with ultraviolet B light (150 mJ per cm(2)). Activators for PPAR-alpha (WY-14,643… CONTINUE READING