Activators of P-glycoprotein: Structure-activity relationships and investigation of their mode of action.

@article{Sterz2009ActivatorsOP,
  title={Activators of P-glycoprotein: Structure-activity relationships and investigation of their mode of action.},
  author={Katja Sterz and Lars M{\"o}llmann and Anna Jacobs and Dieter Baumert and Michael Wiese},
  journal={ChemMedChem},
  year={2009},
  volume={4 11},
  pages={1897-911}
}
P-glycoprotein (P-gp), a 170 kDa plasma membrane protein, is one of the most relevant ABC transporters involved in the development of multidrug resistance (MDR). Understanding its mechanism of transport as well as its interactions with various substrates are basic requirements for the development of adequate therapeutic approaches to overcome this kind of resistance against a broad spectrum of structurally unrelated cytostatic drugs. P-gp modulators (activators) that exert various effects on… CONTINUE READING
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