Activators of G-protein signaling 3: a drug addiction molecular gateway.

  title={Activators of G-protein signaling 3: a drug addiction molecular gateway.},
  author={Michael Scott Bowers},
  journal={Behavioural pharmacology},
  volume={21 5-6},
Drug addiction is marked by continued drug-seeking behavior despite deleterious consequences and a heightened propensity to relapse not withstanding long, drug-free periods. The enduring nature of addiction has been hypothesized to arise from perturbations in intracellular signaling, gene expression, and brain circuitry induced by substance abuse. Ameliorating some of these aberrations should abate behavioral and neurochemical markers associated with an 'addiction phenotype'. This review… CONTINUE READING
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