Activator protein-2gamma (AP-2gamma) expression is specifically induced by oestrogens through binding of the oestrogen receptor to a canonical element within the 5'-untranslated region.

Abstract

The activator protein 2 (AP-2) transcription factors are essential proteins for oestrogenic repression of the ERBB2 proto-oncogene in breast cancer cells. In the present study, we have examined the possible oestrogenic regulation of AP-2 genes themselves in breast-tumour-derived lines. As early as 1 h after oestrogen treatment, AP-2gamma mRNA was markedly… (More)

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@article{Orso2004ActivatorP, title={Activator protein-2gamma (AP-2gamma) expression is specifically induced by oestrogens through binding of the oestrogen receptor to a canonical element within the 5'-untranslated region.}, author={Francesca Orso and Erika Cottone and Mark D Hasleton and J Claire Ibbitt and Piero Sismondi and Helen C. Hurst and Michele De Bortoli}, journal={The Biochemical journal}, year={2004}, volume={377 Pt 2}, pages={429-38} }