Activator protein-2 impairs the invasion of a human extravillous trophoblast cell line.

@article{Kotani2009ActivatorPI,
  title={Activator protein-2 impairs the invasion of a human extravillous trophoblast cell line.},
  author={Tomomi Kotani and Akira Iwase and Kazuhiko Ino and Seiji Sumigama and Eiko Yamamoto and Hiromi Hayakawa and Tetsuo Nagasaka and Atsuo Itakura and Seiji Nomura and Fumitaka Kikkawa},
  journal={Endocrinology},
  year={2009},
  volume={150 9},
  pages={4376-85}
}
The reduced migration/invasion of extravillous trophoblasts (EVTs) is a key feature of the genesis of preeclampsia. We and others previously reported that transcriptional factors activator protein-2 (AP-2) alpha and AP-2gamma act as suppressors of tumor invasion. The present study examined the expressions of AP-2alpha and AP-2gamma in preeclamptic placenta vs. control placenta and investigated their effect on the function of EVTs. The expressions of AP-2alpha and AP-2gamma were elevated in the… CONTINUE READING

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