Activator protein-1 mediates induced but not basal epidermal growth factor receptor gene expression.

@article{Johnson2000ActivatorPM,
  title={Activator protein-1 mediates induced but not basal epidermal growth factor receptor gene expression.},
  author={Aaron Johnson and Barbara A. Murphy and C M Matelis and Yaffa R Rubinstein and E C Piebenga and Latania M Akers and Gila I Neta and Charles Vinson and Michael Birrer},
  journal={Molecular medicine},
  year={2000},
  volume={6 1},
  pages={
          17-27
        }
}
BACKGROUND The epidermal growth factor receptor (EGFR) is expressed at different levels in many cell types and found overexpressed in many cancers. EGFR expression is increased or decreased in response to extracellular stimuli. We examined the effect of increased c-Jun expression on EGFR promoter activity. MATERIALS AND METHODS We used DNAse I foot-printing analysis to determine the binding of activator protein 1 (AP-1) to the promoter region. We also used cotransfection experiments and… CONTINUE READING