Activator protein-1 activation in acute lung injury.

@article{Guo2002ActivatorPA,
  title={Activator protein-1 activation in acute lung injury.},
  author={Ren-feng Guo and Alex B. Lentsch and J. Vidya Sarma and Lei Sun and Niels C. Riedemann and Shannon D. McClintock and Stephanie R. McGuire and Nico Van Rooijen and Peter A Ward},
  journal={The American journal of pathology},
  year={2002},
  volume={161 1},
  pages={
          275-82
        }
}
The role of activator protein-1 (AP-1) in inflammation is primarily unknown. AP-1 was evaluated in nuclear extracts from alveolar macrophages and whole lung nuclear extracts during acute lung injury after deposition of IgG immune complexes. AP-1 activation occurred in macrophages and in whole lung extracts, but with distinctly different time courses. Low levels of constitutive AP-1 were observed in normal rat lung as determined by the electrophoretic mobility shift assay. Increased AP-1 was… CONTINUE READING

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