Activations of mitogen-activated protein kinases and regulation of their downstream molecules after rat lung transplantation from donors after cardiac death.

@article{Yamamoto2011ActivationsOM,
  title={Activations of mitogen-activated protein kinases and regulation of their downstream molecules after rat lung transplantation from donors after cardiac death.},
  author={Seiichiro Yamamoto and Masaomi Yamane and Osamu Yoshida and Mikio Okazaki and Naohisa Waki and Shinichi Toyooka and Takahiro Oto and Shinichiro Miyoshi},
  journal={Transplantation proceedings},
  year={2011},
  volume={43 10},
  pages={3628-33}
}
OBJECTIVES Accepting organs donated after cardiac death (DCD) is an effective approach to the donor shortage. However, lung transplantations from DCD donors show severe rapid pulmonary graft dysfunction (PGD) followed by warm ischemia-reperfusion injury (IRI). This study sought to clarify the molecular mediators in warm IRI, including activation of mitogen-activated protein kinase (MAPK) and the downstream cascades. METHODS We performed single left lung transplantation using organs from male… CONTINUE READING