Activation-triggered subunit exchange between CaMKII holoenzymes facilitates the spread of kinase activity

  title={Activation-triggered subunit exchange between CaMKII holoenzymes facilitates the spread of kinase activity},
  author={Margaret M. Stratton and Il-Hyung Lee and Moitrayee Bhattacharyya and Sune M. Christensen and Luke H Chao and Howard Schulman and Jay T. Groves and John Kuriyan},
The activation of the dodecameric Ca(2+)/calmodulin dependent kinase II (CaMKII) holoenzyme is critical for memory formation. We now report that CaMKII has a remarkable property, which is that activation of the holoenzyme triggers the exchange of subunits between holoenzymes, including unactivated ones, enabling the calcium-independent phosphorylation of new subunits. We show, using a single-molecule TIRF microscopy technique, that the exchange process is triggered by the activation of CaMKII… CONTINUE READING
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