Activation state alters the effect of dietary fatty acids on pro-inflammatory mediator production by murine macrophages.

@article{Wallace2000ActivationSA,
  title={Activation state alters the effect of dietary fatty acids on pro-inflammatory mediator production by murine macrophages.},
  author={F. Wallace and E. Miles and P. Calder},
  journal={Cytokine},
  year={2000},
  volume={12 9},
  pages={
          1374-9
        }
}
  • F. Wallace, E. Miles, P. Calder
  • Published 2000
  • Biology, Medicine
  • Cytokine
  • Studies investigating the effect of dietary fats on pro-inflammatory cytokine production by macrophages (M phis) have yielded conflicting results. We hypothesised that this may be due to the different capacities of the M phis studied commonly (resident, thioglycollate-elicited) to produce prostaglandin E(2)(PGE(2)) and leukotriene B(4)(LTB(4)) which inhibit and stimulate, respectively, tumour necrosis factor-alpha (TNF-alpha) and interleukin-1 beta (IL-1 beta) production. To investigate this… CONTINUE READING
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