Activation processes in ligand-activated G protein-coupled receptors: A case study of the adenosine A2A receptor.

Abstract

Here we review concepts related to an ensemble description of G-protein-coupled receptors (GPCRs). The ensemble is characterized by both inactive and active states, whose equilibrium populations and exchange rates depend sensitively on ligand, environment, and allosteric factors. This review focuses on the adenosine A2 receptor (A2A R), a prototypical class… (More)
DOI: 10.1002/bies.201700072

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