Activation pathways implicate anti-HLA-DP and anti-LFA-1 antibodies as lead candidates for intervention in chronic berylliosis.

@article{Chou2005ActivationPI,
  title={Activation pathways implicate anti-HLA-DP and anti-LFA-1 antibodies as lead candidates for intervention in chronic berylliosis.},
  author={Yuan K. Chou and David M. Edwards and Andrew D. Weinberg and Arthur A. Vandenbark and Brian L. Kotzin and Andrew P Fontenot and Gregory G. Burrows},
  journal={Journal of immunology},
  year={2005},
  volume={174 7},
  pages={
          4316-24
        }
}
CD4(+) T cells play a key role in granulomatous inflammation in the lung of patients with chronic beryllium disease. The goal of this study was to characterize activation pathways of beryllium-responsive bronchoalveolar lavage (BAL) CD4(+) T cells from chronic beryllium disease patients to identify possible therapeutic interventional strategies. Our results demonstrate that in the presence of APCs, beryllium induced strong proliferation responses of BAL CD4(+) T cells, production of… CONTINUE READING

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