Activation ofraf-1, MEK, and MAP kinase in prolactin responsive mammary cells

@article{Das1996ActivationOM,
  title={Activation ofraf-1, MEK, and MAP kinase in prolactin responsive mammary cells},
  author={Rina Banerjee Das and Barbara K. Vonderhaar},
  journal={Breast Cancer Research and Treatment},
  year={1996},
  volume={40},
  pages={141-149}
}
The polypeptide hormone prolactin (Prl), acting through its cell surface receptors, promotes growth and differentiation in normal and malignant breast cells. We demonstrate herein that two Prl-responsive cell lines, NOG-8 normal mouse mammary epithelial and T47D human breast cancer cells, respond to Prl by rapid and transient activation of a series of kinases.Raf-1 was activated within 2–5 min of Prl treatment. This was followed rapidly by activation of MEK (MAP kinase kinase) and MAP kinase… CONTINUE READING
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