Activation of voltage-dependent calcium channels in Kupffer cells by chronic treatment with alcohol in the rat.

@article{Goto1993ActivationOV,
  title={Activation of voltage-dependent calcium channels in Kupffer cells by chronic treatment with alcohol in the rat.},
  author={Matsumi Goto and John J. Lemasters and Ronald G. Thurman},
  journal={The Journal of pharmacology and experimental therapeutics},
  year={1993},
  volume={267 3},
  pages={1264-8}
}
Calcium is essential for activation of Kupffer cells and it was recently reported that Kupffer cells contain L-type voltage-dependent Ca++ channels. The purpose of the present study was to evaluate the effect of chronic ethanol treatment on Ca++ channels. Kupffer cells were isolated from rats fed either a control liquid diet or a liquid ethanol-containing diet for 5 to 8 weeks. The cytosolic free calcium concentration ([Ca++]i) was measured in freshly isolated Kupffer cells with the fluorescent… CONTINUE READING

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