Activation of vocal fold healing with topical vitamin A in rabbits.


CONCLUSION The results suggest that vitamin A can prevent scar formation in the vocal fold after surgery. OBJECTIVES This study aimed to evaluate the effects of topically applied vitamin A on healing after vocal fold trauma. MATERIALS AND METHODS Vocal folds of 20 adult rabbits were traumatized unilaterally. Ten of them were treated with topical application of vitamin A and the others served as controls. All animals were sacrificed after 10 days. Vocal folds were resected for analysis by light microscopy. RESULTS The untreated vocal folds showed extensive deposition of collagen and fibroblast on light microscopy and vocal folds treated with vitamin A showed less deposition. There was a significant difference between the two groups according to the percentage of collagen and fibroblasts in the lamina propria (p<0.01).

DOI: 10.1080/00016480802087219

Cite this paper

@article{Akdogan2009ActivationOV, title={Activation of vocal fold healing with topical vitamin A in rabbits.}, author={Ozgur Akdogan and Adin Selçuk and Ibrahim Ozcan and K{\"{u}rşat Murat Ozcan and Seren Gulsen Giray and Huseyin Dere and Candan Ozoğul}, journal={Acta oto-laryngologica}, year={2009}, volume={129 2}, pages={220-4} }