Activation of virus replication after vaccination of HIV-1-infected individuals

  title={Activation of virus replication after vaccination of HIV-1-infected individuals},
  author={Silvija I. Staprans and Brian L Hamilton and Stephen E Follansbee and Tarek A Elbeik and Peter Barbosa and Robert M. Grant and Mark B. Feinberg},
  journal={The Journal of Experimental Medicine},
  pages={1727 - 1737}
Little is known about the factors that govern the level of HIV-1 replication in infected individuals. Recent studies (using potent antiviral drugs) of the kinetics of HIV-1 replication in vivo have demonstrated that steady-state levels of viremia are sustained by continuous rounds of de novo infection and the associated rapid turnover of CD4+ T lymphocytes. However, no information is available concerning the biologic variables that determine the size of the pool of T cells that are susceptible… CONTINUE READING
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