Activation of ventrolateral preoptic neurons by the somnogen prostaglandin D2.

@article{Scammell1998ActivationOV,
  title={Activation of ventrolateral preoptic neurons by the somnogen prostaglandin D2.},
  author={Thomas E Scammell and Dmitry Y. Gerashchenko and Yoshihiro Urade and Hirotaka Onoe and Clifford B. Saper and Osamu Hayaishi},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1998},
  volume={95 13},
  pages={7754-9}
}
Prostaglandin D2 (PGD2) is an extensively studied sleep-promoting substance, but the neuroanatomical basis of PGD2-induced sleep is only partially understood. To determine potential regions involved in this response, we used Fos immunohistochemistry to identify neurons activated by infusion of PGD2 into the subarachnoid space below the rostral basal forebrain. PGD2 increased nonrapid eye movement sleep and induced striking expression of Fos in the ventrolateral preoptic area (VLPO), a cluster… CONTINUE READING