Activation of vascular endothelial growth factor receptor-3 in macrophages restrains TLR4-NF-κB signaling and protects against endotoxin shock.

@article{Zhang2014ActivationOV,
  title={Activation of vascular endothelial growth factor receptor-3 in macrophages restrains TLR4-NF-κB signaling and protects against endotoxin shock.},
  author={Yanbo Zhang and Yao Lu and Li Ma and Xudong Cao and Jun Xiao and Jiexia Chen and Shaozhuo Jiao and Yunzhen Gao and Changming Liu and Zhao-jun Duan and Dangsheng Li and Yulong He and Bin Wei and Hong-yan Wang},
  journal={Immunity},
  year={2014},
  volume={40 4},
  pages={501-14}
}
Toll-like receptors (TLRs) are critical in mediating innate immune responses against infections. However, uncontrolled TLR-triggered inflammation is associated with endotoxin shock. To better understand the homeostatic mechanisms induced by TLR4 signaling, we screened a group of key cytokines, chemokines, growth factors, and their receptors for bacteria- or LPS-induced expression. The surface vascular endothelial growth factor receptor-3 (VEGFR-3) and its ligand VEGF-C were upregulated in… CONTINUE READING
Recent Discussions
This paper has been referenced on Twitter 2 times over the past 90 days. VIEW TWEETS
33 Citations
53 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-10 of 33 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 53 references

Similar Papers

Loading similar papers…