Activation of vascular endothelial growth factor gene transcription by hypoxia-inducible factor 1.

@article{Forsythe1996ActivationOV,
  title={Activation of vascular endothelial growth factor gene transcription by hypoxia-inducible factor 1.},
  author={J. Forsythe and B. Jiang and N. Iyer and F. Agani and S. Leung and R. Koos and G. Semenza},
  journal={Molecular and cellular biology},
  year={1996},
  volume={16},
  pages={4604 - 4613}
}
  • J. Forsythe, B. Jiang, +4 authors G. Semenza
  • Published 1996
  • Biology, Medicine
  • Molecular and cellular biology
  • Expression of vascular endothelial growth factor (VEGF) is induced in cells exposed to hypoxia or ischemia. Neovascularization stimulated by VEGF occurs in several important clinical contexts, including myocardial ischemia, retinal disease, and tumor growth. Hypoxia-inducible factor 1 (HIF-1) is a heterodimeric basic helix-loop-helix protein that activates transcription of the human erythropoietin gene in hypoxic cells. Here we demonstrate the involvement of HIF-1 in the activation of VEGF… CONTINUE READING
    3,467 Citations
    RTEF-1, a Novel Transcriptional Stimulator of Vascular Endothelial Growth Factor in Hypoxic Endothelial Cells*
    • 47
    • PDF
    Role of hypoxia-inducible factor 1alpha in gastric cancer cell growth, angiogenesis, and vessel maturation.
    • 230
    • PDF
    Hypoxia and interleukin-1beta stimulate vascular endothelial growth factor production in human proximal tubular cells.
    • 121

    References

    SHOWING 1-10 OF 67 REFERENCES
    Transcriptional Regulation of the Rat Vascular Endothelial Growth Factor Gene by Hypoxia (*)
    • 1,118
    • Highly Influential
    • PDF
    Hypoxia regulates vascular endothelial growth factor gene expression in endothelial cells. Identification of a 5' enhancer.
    • 934
    • Highly Influential
    Hypoxia regulatory elements of the human vascular endothelial growth factor gene.
    • 215
    Hypoxia-induced Transcriptional Activation and Increased mRNA Stability of Vascular Endothelial Growth Factor in C6 Glioma Cells (*)
    • 614
    • PDF
    General involvement of hypoxia-inducible factor 1 in transcriptional response to hypoxia.
    • G. Wang, G. Semenza
    • Biology, Medicine
    • Proceedings of the National Academy of Sciences of the United States of America
    • 1993
    • 1,268
    • PDF
    Characterization of hypoxia-inducible factor 1 and regulation of DNA binding activity by hypoxia.
    • 834
    Post-transcriptional Regulation of Vascular Endothelial Growth Factor by Hypoxia (*)
    • 669
    • PDF
    Transcriptional regulation of genes encoding glycolytic enzymes by hypoxia-inducible factor 1.
    • 1,590
    Hypoxia is a strong inducer of vascular endothelial growth factor mRNA expression in the heart.
    • A. Ladoux, C. Frelin
    • Biology, Medicine
    • Biochemical and biophysical research communications
    • 1993
    • 310