Activation of vascular endothelial growth factor receptor-3 and its downstream signaling promote cell survival under oxidative stress.

@article{Wang2004ActivationOV,
  title={Activation of vascular endothelial growth factor receptor-3 and its downstream signaling promote cell survival under oxidative stress.},
  author={Jian Feng Wang and Xuefeng Zhang and Jerome E. Groopman},
  journal={The Journal of biological chemistry},
  year={2004},
  volume={279 26},
  pages={27088-97}
}
Reactive oxygen species (ROS) mediate cell damage and have been implicated in the pathogenesis of diseases that involve endothelial injury. Cells possess antioxidant systems, including intracellular antioxidants and ROS scavenging enzymes, that control the redox state and prevent cell damage. In addition to intracellular antioxidants, certain growth factor receptors can be activated under oxidative stress and trigger downstream cell survival signaling cascades. Vascular endothelial growth… CONTINUE READING
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