Activation of vascular endothelial cell adhesion molecule expression by sickle blood cells.

@article{Brown2001ActivationOV,
  title={Activation of vascular endothelial cell adhesion molecule expression by sickle blood cells.},
  author={Michael D. Brown and Timothy M. Wick and James R. Eckman},
  journal={Pediatric pathology & molecular medicine},
  year={2001},
  volume={20 1},
  pages={47-72}
}
Microvascular complications in sickle cell disease occur as a result of obstruction of small vessels by deoxygenated sickle cells. Cerebrovascular complications are also common and result from obstruction of large blood vessels by thrombosis with changes in vessels that have some similarity to those found in arteriosclerotic vascular disease. Endothelial damage and activation from sickle cell-endothelial interactions may contribute to both. We find that endothelial cells have increased… CONTINUE READING

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