Activation of uPAR is required for cigarette smoke extract-induced epithelial-mesenchymal transition in lung epithelial cells.

@article{Wang2013ActivationOU,
  title={Activation of uPAR is required for cigarette smoke extract-induced epithelial-mesenchymal transition in lung epithelial cells.},
  author={Qin Wang and Hongchao Wang and Yi Zhang and Yuke Zhang and Wei Xiao},
  journal={Oncology research},
  year={2013},
  volume={21 6},
  pages={
          295-305
        }
}
Cigarette smoke is a major risk factor for lung cancer, which may contribute to lung cancer invasion and metastasis. However, the mechanism remains unclear. Epithelial-mesenchymal transition (EMT) is a critical phenotypic alteration of cells that triggers invasion and metastasis. The urokinase-type plasminogen activator receptor (uPAR) is originally thought to assist the directional invasion of migrating cells, and increasing evidences show that overexpression of uPAR in cancer cells promotes… CONTINUE READING
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