Activation of type IV procollagenases by human tumor-associated trypsin-2.

  title={Activation of type IV procollagenases by human tumor-associated trypsin-2.},
  author={Timo Sorsa and Tuula Salo and Erkki Koivunen and Jaana Tyynel{\"a} and Yrjo T Konttinen and Ulrich Bergmann and Ari Tuuttila and Ernie Niemi and Olli P Teronen and Pia Heikkil{\"a} and Harald Tschesche and Jari T Leinonen and Safiye Osman and Ulf Hakan Stenman},
  journal={The Journal of biological chemistry},
  volume={272 34},
Increased production of proteinases, such as matrix metalloproteinases (MMPs), is a characteristic feature of malignant tumors. Some human cancers and cell lines derived from them also express trypsinogen, but the function of the extrapancreatic trypsin has remained unclear. In this study we cloned and sequenced trypsinogen-2 cDNA from human COLO 205 colon carcinoma cells and characterized the ability of the enzyme to activate latent human type IV procollagenases (proMMP-2 and proMMP-9). As… CONTINUE READING
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