Activation of type II NADH dehydrogenase by quinolinequinones mediates antitubercular cell death.

Abstract

OBJECTIVES Quinolinequinones (QQ) have been shown to inhibit the growth of mycobacterial species, but their mode(s) of action and molecular target(s) remain unknown. To facilitate further development of QQ as antimycobacterial drugs, we investigated the molecular mechanism and target of QQ in mycobacteria. METHODS Cell viability of Mycobacterium… (More)
DOI: 10.1093/jac/dkw244

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Cite this paper

@article{Heikal2016ActivationOT, title={Activation of type II NADH dehydrogenase by quinolinequinones mediates antitubercular cell death.}, author={Adam Heikal and Kiel J Hards and C. T. Cheung and Ayana Menorca and Mattie S M Timmer and Bridget Louise Stocker and G. Cook}, journal={The Journal of antimicrobial chemotherapy}, year={2016}, volume={71 10}, pages={2840-7} }