Activation of two distinct Sox9-EGFP-expressing intestinal stem cell populations during crypt regeneration after irradiation.

@article{Landeghem2012ActivationOT,
  title={Activation of two distinct Sox9-EGFP-expressing intestinal stem cell populations during crypt regeneration after irradiation.},
  author={Laurianne Van Landeghem and Maria Agostina Santoro and Adrienne E. Krebs and Amanda T. Mah and Jeffrey J. Dehmer and Adam D. Gracz and Brooks P. Scull and Kirk K. McNaughton and Scott T. Magness and Pauline Kay Lund},
  journal={American journal of physiology. Gastrointestinal and liver physiology},
  year={2012},
  volume={302 10},
  pages={G1111-32}
}
Recent identification of intestinal epithelial stem cell (ISC) markers and development of ISC reporter mice permit visualization and isolation of regenerating ISCs after radiation to define their functional and molecular phenotypes. Previous studies in uninjured intestine of Sox9-EGFP reporter mice demonstrate that ISCs express low levels of Sox9-EGFP (Sox9-EGFP Low), whereas enteroendocrine cells (EEC) express high levels of Sox9-EGFP (Sox9-EGFP High). We hypothesized that Sox9-EGFP Low ISCs… CONTINUE READING
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